LKT Labs 是一家專注于防癌抗癌特殊化學品研究和開發(fā)的公司。主要提供：癌癥藥物、藥物發(fā)現(xiàn)試劑盒、天然產(chǎn)物、廣泛的生命科學研究試劑、定制合成。
美國LKT Labs 是1988年在美國成立的，為全球提供先端的藥物研發(fā)試劑、試劑盒、委托合成，并為藥物生產(chǎn)企業(yè)提供原料，最近幾年在農(nóng)藥、水產(chǎn)養(yǎng)殖業(yè)有很大程度的開發(fā)。在LKT Labs 可以找到在其他地方找不到的產(chǎn)品。

LKT Labs C0366 Carvedilol Phosphate

LKT Labs C0366 Carvedilol Phosphate

LKT Labs 代理銷售 一級代理

LKT Labs 代理銷售 一級代理

LKT O4531 Oligomycin A 5 mg 318.2 Macrolide; F1F0 ATP synthase inhibitor. 579-13-5 ≥97%, TLC, HPLC 791.06 C45H74O11 CCC1CCC2C(C(C(C3(O2)CCC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C Ambient 4°C Soluble in DMSO, ethanol, acetone. "He L, Jang JH, Choi HG, et al. Oligomycin A enhances apoptotic effect of TRAIL through CHOP-mediated death receptor 5 expression. Mol Carcinog. 2013 Feb;52(2):85-93. PMID: 23335397.

Ponnala S, Chetty C, Veeravalli KK, et al. Metabolic remodeling precedes mitochondrial outer membrane permeabilization in human glioma xenograft cells. Int J Oncol. 2012 Feb;40(2):509-18. PMID: 22076676.

Yang PW, Li MG, Zhao JY, et al. Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus. Folia Microbiol (Praha). 2010 Jan;55(1):10-6. PMID: 20336498.

" Not dangerous goods.

LKT O4532 Oligomycin B 1 mg 77.1 Macrolide; F1F0 ATP synthase inhibitor. 11050-94-5 ≥97%, TLC, HPLC 805.05 C45H72O12 CCC1CCC2C(C(C(C3(O2)C(=O)CC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C Ambient 4°C Soluble in DMSO, ethanol, acetone. "Grover GJ, Malm J. Pharmacological profile of the selective mitochondrial F1F0 ATP hydrolase inhibitor BMS-199264 in myocardial ischemia. Cardiovasc Ther. 2008 Winter;26(4):287-96. PMID: 19035880.

Grover GJ, Atwal KS, Sleph PG, et al. Excessive ATP hydrolysis in ischemic myocardium by mitochondrial F1F0-ATPase: effect of selective pharmacological inhibition of mitochondrial ATPase hydrolase activity. Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1747-55. Erratum in: Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H484.  PMID: 15371268.

Koos BJ, Sameshima H, Power GG. Fetal breathing movement, sleep state and cardiovascular responses to an inhibitor of mitochondrial ATPase in sheep. J Dev Physiol. 1986 Feb;8(1):67-75. PMID: 2937831.

" Xn Not dangerous goods.

LKT O4532 Oligomycin B 5 mg 318.2 Macrolide; F1F0 ATP synthase inhibitor. 11050-94-5 ≥97%, TLC, HPLC 805.05 C45H72O12 CCC1CCC2C(C(C(C3(O2)C(=O)CC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C Ambient 4°C Soluble in DMSO, ethanol, acetone. "Grover GJ, Malm J. Pharmacological profile of the selective mitochondrial F1F0 ATP hydrolase inhibitor BMS-199264 in myocardial ischemia. Cardiovasc Ther. 2008 Winter;26(4):287-96. PMID: 19035880.

Grover GJ, Atwal KS, Sleph PG, et al. Excessive ATP hydrolysis in ischemic myocardium by mitochondrial F1F0-ATPase: effect of selective pharmacological inhibition of mitochondrial ATPase hydrolase activity. Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1747-55. Erratum in: Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H484.  PMID: 15371268.

Koos BJ, Sameshima H, Power GG. Fetal breathing movement, sleep state and cardiovascular responses to an inhibitor of mitochondrial ATPase in sheep. J Dev Physiol. 1986 Feb;8(1):67-75. PMID: 2937831.

" Xn Not dangerous goods.

LKT T1855 Tentoxin 1 mg 693.2 Cyclic peptide mycotoxin produced by Alternaria; CF1 ATPase inhibitor. Cycloleucyl-N-methylalanylglycyl-N-methyl dehydrophenylalanine 28540-82-1 ≥98%, HPLC 414.5 C22H30N4O4 CC1C(=O)NC(C(=O)N(C(=CC2=CC=CC=C2)C(=O)NCC(=O)N1C)C)CC(C)C Ambient 4°C Soluble in DMSO (10 mg/mL), methanol (10 mg/mL), ethanol (10 mg/mL. "Duke SO, Dayan FE. Modes of action of microbially-produced phytotoxins. Toxins (Basel). 2011 Aug;3(8):1038-64. Erratum in: Toxins (Basel). 2012;4(10):955.  PMID: 22069756.

Reimer S, Selman BR. Tentoxin-induced energy-independent adenine nucleotide exchange and ATPase activity with chloroplast coupling factor 1. J Biol Chem. 1978 Oct 25;253(20):7249-55. PMID: 151681.

Selman BR, Durbin RD. Evidence for a catalytic function of the coupling factor 1 protein reconstituted with chloroplast thylakoid membranes. Biochim Biophys Acta. 1978 Apr 11;502(1):29-37. PMID: 147703.

" T Not dangerous goods.

LKT T1855 Tentoxin 5 mg 2765.8 Cyclic peptide mycotoxin produced by Alternaria; CF1 ATPase inhibitor. Cycloleucyl-N-methylalanylglycyl-N-methyl dehydrophenylalanine 28540-82-1 ≥98%, HPLC 414.5 C22H30N4O4 CC1C(=O)NC(C(=O)N(C(=CC2=CC=CC=C2)C(=O)NCC(=O)N1C)C)CC(C)C Ambient 4°C Soluble in DMSO (10 mg/mL), methanol (10 mg/mL), ethanol (10 mg/mL. "Duke SO, Dayan FE. Modes of action of microbially-produced phytotoxins. Toxins (Basel). 2011 Aug;3(8):1038-64. Erratum in: Toxins (Basel). 2012;4(10):955.  PMID: 22069756.

Reimer S, Selman BR. Tentoxin-induced energy-independent adenine nucleotide exchange and ATPase activity with chloroplast coupling factor 1. J Biol Chem. 1978 Oct 25;253(20):7249-55. PMID: 151681.

Selman BR, Durbin RD. Evidence for a catalytic function of the coupling factor 1 protein reconstituted with chloroplast thylakoid membranes. Biochim Biophys Acta. 1978 Apr 11;502(1):29-37. PMID: 147703.

" T Not dangerous goods.

LKT T1952 Tenuazonic Acid 1 mg 67.9 Mycotoxin produced by Alternaria; photosynthesis inhibitor. "3-Pyrrolin-2-one, 3-acetyl-5-sec-butyl-4-hydroxy-, L-

L-Tenuazonic acid" 610-88-8 ≥96% 197.23 C10H15NO3 CCC(C)C1C(=C(C(=O)N1)C(=O)C)O Ambient 4°C Soluble in DMSO and ethanol. "Schwarz C, Kreutzer M, Marko D. Minor contribution of alternariol, alternariol monomethyl ether and tenuazonic acid to the genotoxic properties of extracts from Alternaria alternata infested rice. Toxicol Lett. 2012 Oct 2;214(1):46-52. PMID: 22906495.

Chen S, Yin C, Qiang S, et al. Chloroplastic oxidative burst induced by tenuazonic acid, a natural photosynthesis inhibitor, triggers cell necrosis in Eupatorium adenophorum Spreng. Biochim Biophys Acta. 2010 Mar;1797(3):391-405. PMID: 20026008.

" T "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Tenuazonic acid)"

LKT T1952 Tenuazonic Acid 5 mg 273 Mycotoxin produced by Alternaria; photosynthesis inhibitor. "3-Pyrrolin-2-one, 3-acetyl-5-sec-butyl-4-hydroxy-, L-

L-Tenuazonic acid" 610-88-8 ≥96% 197.23 C10H15NO3 CCC(C)C1C(=C(C(=O)N1)C(=O)C)O Ambient 4°C Soluble in DMSO and ethanol. "Schwarz C, Kreutzer M, Marko D. Minor contribution of alternariol, alternariol monomethyl ether and tenuazonic acid to the genotoxic properties of extracts from Alternaria alternata infested rice. Toxicol Lett. 2012 Oct 2;214(1):46-52. PMID: 22906495.

Chen S, Yin C, Qiang S, et al. Chloroplastic oxidative burst induced by tenuazonic acid, a natural photosynthesis inhibitor, triggers cell necrosis in Eupatorium adenophorum Spreng. Biochim Biophys Acta. 2010 Mar;1797(3):391-405. PMID: 20026008.

" T "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Tenuazonic acid)"

LKT T7676 HT-2 Toxin 1 mg 258 Trichothecene mycotoxin produced by Fusarium. 26934-87-2 ≥98%, TLC, HPLC 424.48 C22H32O8 CC1=CC2C(CC1OC(=O)CC(C)C)(C3(C(C(C(C34CO4)O2)O)O)C)COC(=O)C Ambient 4°C Soluble in Ethanol, DMSO.  Very slightly soluble in water. "Ortiz J, Van Camp J, Mestdagh F, et al. Mycotoxin co-occurrence in rice, oat flakes and wheat noodles used as staple foods in Ecuador. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013 Dec 7. [Epub ahead of print]. PMID: 24313870.

Weidner M, Hüwel S, Ebert F, et al. Influence of T-2 and HT-2 toxin on the blood-brain barrier in vitro: new experimental hints for neurotoxic effects. PLoS One. 2013;8(3):e60484. PMID: 23544145.

" Xi, Xn, T+ "UN number: 3462     Class: 6.1     Packing Group: I

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (HT-2 Toxin)"

LKT T7676 HT-2 Toxin 5 mg 1021.2 Trichothecene mycotoxin produced by Fusarium. 26934-87-2 ≥98%, TLC, HPLC 424.48 C22H32O8 CC1=CC2C(CC1OC(=O)CC(C)C)(C3(C(C(C(C34CO4)O2)O)O)C)COC(=O)C Ambient 4°C Soluble in Ethanol, DMSO.  Very slightly soluble in water. "Ortiz J, Van Camp J, Mestdagh F, et al. Mycotoxin co-occurrence in rice, oat flakes and wheat noodles used as staple foods in Ecuador. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013 Dec 7. [Epub ahead of print]. PMID: 24313870.

Weidner M, Hüwel S, Ebert F, et al. Influence of T-2 and HT-2 toxin on the blood-brain barrier in vitro: new experimental hints for neurotoxic effects. PLoS One. 2013;8(3):e60484. PMID: 23544145.

" Xi, Xn, T+ "UN number: 3462     Class: 6.1     Packing Group: I

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (HT-2 Toxin)"

LKT T3134 Thiostrepton 1 g 231.1 Thiazole; proteasome inhibitor, protein translocation inhibitor. 1393-48-2 ≥97%, HPLC 1664.89 C72H85N19O18S5 CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)C(=CC)NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C Ambient 4°C Practically insoluble in water.  Soluble in chloroform, dichloromethane, DMF.  DMSO solution (1 %) is unstable - should be freshly prepared. "Newick K, Cunniff B, Preston K, et al. Peroxiredoxin 3 is a redox-dependent target of thiostrepton in malignant mesothelioma cells. PLoS One. 2012;7(6):e39404. PMID: 22761781

Rodnina MV, Savelsbergh A, Matassova NB, et al. Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9586-90. PMID: 10449736.

Naaktgeboren N, Roobol K, Gubbens J, et al. The mode of action of thiostrepton in the initiation of protein synthesis. Eur J Biochem. 1976 Nov 1;70(1):39-47. PMID: 795651.

" Xn Not dangerous goods.

LKT T3134 Thiostrepton 5 g 927.7 Thiazole; proteasome inhibitor, protein translocation inhibitor. 1393-48-2 ≥97%, HPLC 1664.89 C72H85N19O18S5 CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)C(=CC)NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C Ambient 4°C Practically insoluble in water.  Soluble in chloroform, dichloromethane, DMF.  DMSO solution (1 %) is unstable - should be freshly prepared. "Newick K, Cunniff B, Preston K, et al. Peroxiredoxin 3 is a redox-dependent target of thiostrepton in malignant mesothelioma cells. PLoS One. 2012;7(6):e39404. PMID: 22761781

Rodnina MV, Savelsbergh A, Matassova NB, et al. Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9586-90. PMID: 10449736.

Naaktgeboren N, Roobol K, Gubbens J, et al. The mode of action of thiostrepton in the initiation of protein synthesis. Eur J Biochem. 1976 Nov 1;70(1):39-47. PMID: 795651.

" Xn Not dangerous goods.

LKT D4802 17-Dimethylaminoethylamino Demethoxygeldanamycin 10 mg 169.9 Geldanamycin derivative; HSP90 inhibitor. 17-DMAG, Alvespimycin 467214-20-6 ≥98% 616.75 C32H48N4O8 CC1CCCC(CCC(=O)OC23C(C=CC1)C(C(=C)C(C2C(NC3=O)CC4=CC=CC=C4)C)O)O Ambient 4°C DMSO, Ethanol "Silva-Fernandes A, Duarte-Silva S, Neves-Carvalho A, et al. Chronic Treatment with 17-DMAG Improves Balance and Coordination in A New Mouse Model of Machado-Joseph Disease. Neurotherapeutics. 2014 Jan 30. [Epub ahead of print]. PMID: 24477711.

Yi B, Yang J, Wang L. The growth inhibitory effect of 17-DMAG on ALK and MYCN double-positive neuroblastoma cell line. Tumour Biol. 2013 Nov 30. [Epub ahead of print]. PMID: 24293393.

Sun X, Bristol JA, Iwahori S, et al. Hsp90 inhibitor 17-DMAG decreases expression of conserved herpesvirus protein kinases and reduces virus production in Epstein-Barr virus-infected cells. J Virol. 2013 Sep;87(18):10126-38. PMID: 23843639.

Ikebe E, Kawaguchi A, Tezuka K, et al. Oral administration of an HSP90 inhibitor, 17-DMAG, intervenes tumor-cell infiltration into multiple organs and improves survival period for ATL model mice. Blood Cancer J. 2013 Aug 16;3:e132. PMID: 23955587.

" Not dangerous goods.

LKT F8147 Fulvestrant 5 mg 47.6 Induces ER degradation. 129453-61-8 ≥98% 606.77 C32H47F5O3S CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F In DMSO at +4 for 2 weeks at -80 for 6 months. Ambient Ambient "Soluble in ethanol (>200 mg/mL), DMSO (>20 mg/mL).  Insoluble in water. DMF 20 mg/mL, chloroform.

" "Edavana VK, Penney RB, Yao-Borengasser A, et al. Fulvestrant up regulates UGT1A4 and MRPs through ERα and c-Myb pathways: a possible primary drug disposition mechanism. Springerplus. 2013 Nov 20;2:620. PMID: 24298433.

Krell J, Januszewski A, Yan K, et al. Role of fulvestrant in the management of postmenopausal breast cancer. Expert Rev Anticancer Ther. 2011 Nov;11(11):1641-52. PMID: 22050013.

Scott SM, Brown M, Come SE. Emerging data on the efficacy and safety of fulvestrant, a unique antiestrogen therapy for advanced breast cancer. Expert Opin Drug Saf. 2011 Sep;10(5):819-26. PMID: 21699443

Camerini A, Rondini M, Garrone O, et al. Fulvestrant treatment is associated with cholesterol plasma level reduction in hormone-receptor-positive metastatic breast cancer patients. Cancer Biol Ther. 2009 Aug;8(15):1450-5. PMID: 19556864.

" Not dangerous goods.

LKT F8147 Fulvestrant 25 mg 136 Induces ER degradation. 129453-61-8 ≥98% 606.77 C32H47F5O3S CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F In DMSO at +4 for 2 weeks at -80 for 6 months. Ambient Ambient "Soluble in ethanol (>200 mg/mL), DMSO (>20 mg/mL).  Insoluble in water. DMF 20 mg/mL, chloroform.

" "Edavana VK, Penney RB, Yao-Borengasser A, et al. Fulvestrant up regulates UGT1A4 and MRPs through ERα and c-Myb pathways: a possible primary drug disposition mechanism. Springerplus. 2013 Nov 20;2:620. PMID: 24298433.

Krell J, Januszewski A, Yan K, et al. Role of fulvestrant in the management of postmenopausal breast cancer. Expert Rev Anticancer Ther. 2011 Nov;11(11):1641-52. PMID: 22050013.

Scott SM, Brown M, Come SE. Emerging data on the efficacy and safety of fulvestrant, a unique antiestrogen therapy for advanced breast cancer. Expert Opin Drug Saf. 2011 Sep;10(5):819-26. PMID: 21699443

Camerini A, Rondini M, Garrone O, et al. Fulvestrant treatment is associated with cholesterol plasma level reduction in hormone-receptor-positive metastatic breast cancer patients. Cancer Biol Ther. 2009 Aug;8(15):1450-5. PMID: 19556864.

" Not dangerous goods.

LKT F8147 Fulvestrant 100 mg 407.7 Induces ER degradation. 129453-61-8 ≥98% 606.77 C32H47F5O3S CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F In DMSO at +4 for 2 weeks at -80 for 6 months. Ambient Ambient "Soluble in ethanol (>200 mg/mL), DMSO (>20 mg/mL).  Insoluble in water. DMF 20 mg/mL, chloroform.

" "Edavana VK, Penney RB, Yao-Borengasser A, et al. Fulvestrant up regulates UGT1A4 and MRPs through ERα and c-Myb pathways: a possible primary drug disposition mechanism. Springerplus. 2013 Nov 20;2:620. PMID: 24298433.

Krell J, Januszewski A, Yan K, et al. Role of fulvestrant in the management of postmenopausal breast cancer. Expert Rev Anticancer Ther. 2011 Nov;11(11):1641-52. PMID: 22050013.

Scott SM, Brown M, Come SE. Emerging data on the efficacy and safety of fulvestrant, a unique antiestrogen therapy for advanced breast cancer. Expert Opin Drug Saf. 2011 Sep;10(5):819-26. PMID: 21699443

Camerini A, Rondini M, Garrone O, et al. Fulvestrant treatment is associated with cholesterol plasma level reduction in hormone-receptor-positive metastatic breast cancer patients. Cancer Biol Ther. 2009 Aug;8(15):1450-5. PMID: 19556864.

" Not dangerous goods.

LKT K1978 Ketorolac Tromethamine 1 g 33.5 NSAID; COX-1/2 inhibitor. 74103-07-4 ≥98% 376.4 C19H24N2O6 C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O Ambient Ambient "Dong L, Smith JR, Winkelstein BA. Ketorolac reduces spinal astrocytic activation and PAR1 expression associated with attenuation of pain after facet joint injury. J Neurotrauma. 2013 May 15;30(10):818-25. PMID: 23126437.

Bendixen KH, Baad-Hansen L, Cairns BE, et al. Effects of low-dose intramuscular ketorolac on experimental pain in the masseter muscle of healthy women. J Orofac Pain. 2010 Fall;24(4):398-407. PMID: 21197512.

Wang XM, Hamza M, Gordon SM, et al. COX inhibitors downregulate PDE4D expression in a clinical model of inflammatory pain. Clin Pharmacol Ther. 2008 Jul;84(1):39-42. PMID: 18288087.

Ma W, Eisenach JC. Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance P, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation. Neuroscience. 2003;121(3):681-90. PMID: 14568028.

" Xi "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Ketorolac tromethamine)"

LKT K1978 Ketorolac Tromethamine 5 g 125.6 NSAID; COX-1/2 inhibitor. 74103-07-4 ≥98% 376.4 C19H24N2O6 C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O Ambient Ambient "Dong L, Smith JR, Winkelstein BA. Ketorolac reduces spinal astrocytic activation and PAR1 expression associated with attenuation of pain after facet joint injury. J Neurotrauma. 2013 May 15;30(10):818-25. PMID: 23126437.

Bendixen KH, Baad-Hansen L, Cairns BE, et al. Effects of low-dose intramuscular ketorolac on experimental pain in the masseter muscle of healthy women. J Orofac Pain. 2010 Fall;24(4):398-407. PMID: 21197512.

Wang XM, Hamza M, Gordon SM, et al. COX inhibitors downregulate PDE4D expression in a clinical model of inflammatory pain. Clin Pharmacol Ther. 2008 Jul;84(1):39-42. PMID: 18288087.

Ma W, Eisenach JC. Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance P, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation. Neuroscience. 2003;121(3):681-90. PMID: 14568028.

" Xi "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Ketorolac tromethamine)"

LKT K1978 Ketorolac Tromethamine 25 g 502.3 NSAID; COX-1/2 inhibitor. 74103-07-4 ≥98% 376.4 C19H24N2O6 C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O Ambient Ambient "Dong L, Smith JR, Winkelstein BA. Ketorolac reduces spinal astrocytic activation and PAR1 expression associated with attenuation of pain after facet joint injury. J Neurotrauma. 2013 May 15;30(10):818-25. PMID: 23126437.

Bendixen KH, Baad-Hansen L, Cairns BE, et al. Effects of low-dose intramuscular ketorolac on experimental pain in the masseter muscle of healthy women. J Orofac Pain. 2010 Fall;24(4):398-407. PMID: 21197512.

Wang XM, Hamza M, Gordon SM, et al. COX inhibitors downregulate PDE4D expression in a clinical model of inflammatory pain. Clin Pharmacol Ther. 2008 Jul;84(1):39-42. PMID: 18288087.

Ma W, Eisenach JC. Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance P, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation. Neuroscience. 2003;121(3):681-90. PMID: 14568028.

" Xi "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Ketorolac tromethamine)"

LKT E5477 Entinostat 1 mg 54.4 Benzamide; HDAC1 inhibitor. N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester SNDX-275; MS-275; 209783-80-2    ≥98% 376.41 C21H20N4O3 C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3 Ambient Ambient "Shah P, Gau Y, Sabnis G. Histone deacetylase inhibitor entinostat reverses epithelial to mesenchymal transition of breast cancer cells by reversing the repression of E-cadherin. Breast Cancer Res Treat. 2013 Dec 5. [Epub ahead of print]. PMID: 24305977.

Zhu S, Denman CJ, Cobanoglu ZS, et al. The Narrow-Spectrum HDAC Inhibitor Entinostat Enhances NKG2D Expression Without NK Cell Toxicity, Leading to Enhanced Recognition of Cancer Cells. Pharm Res. 2013 Nov 8. [Epub ahead of print]. PMID: 24203492.

Kennedy PJ, Feng J, Robison AJ, et al. Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nat Neurosci. 2013 Apr;16(4):434-40. PMID: 23475113.

Rao-Bindal K, Koshkina NV, Stewart J, et al. The histone deacetylase inhibitor, MS-275 (entinostat), downregulates c-FLIP, sensitizes osteosarcoma cells to FasL, and induces the regression of osteosarcoma lung metastases. Curr Cancer Drug Targets. 2013 May;13(4):411-22. PMID: 23410027.

Zhang ZY, Schluesener HJ. Oral administration of histone deacetylase inhibitor MS-275 ameliorates neuroinflammation and cerebral amyloidosis and improves behavior in a mouse model. J Neuropathol Exp Neurol. 2013 Mar;72(3):178-85. PMID: 23399896.

" Xi Not dangerous goods.

LKT E5477 Entinostat 5 mg 212.3 Benzamide; HDAC1 inhibitor. N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester SNDX-275; MS-275; 209783-80-2    ≥98% 376.41 C21H20N4O3 C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3 Ambient Ambient "Shah P, Gau Y, Sabnis G. Histone deacetylase inhibitor entinostat reverses epithelial to mesenchymal transition of breast cancer cells by reversing the repression of E-cadherin. Breast Cancer Res Treat. 2013 Dec 5. [Epub ahead of print]. PMID: 24305977.

Zhu S, Denman CJ, Cobanoglu ZS, et al. The Narrow-Spectrum HDAC Inhibitor Entinostat Enhances NKG2D Expression Without NK Cell Toxicity, Leading to Enhanced Recognition of Cancer Cells. Pharm Res. 2013 Nov 8. [Epub ahead of print]. PMID: 24203492.

Kennedy PJ, Feng J, Robison AJ, et al. Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nat Neurosci. 2013 Apr;16(4):434-40. PMID: 23475113.

Rao-Bindal K, Koshkina NV, Stewart J, et al. The histone deacetylase inhibitor, MS-275 (entinostat), downregulates c-FLIP, sensitizes osteosarcoma cells to FasL, and induces the regression of osteosarcoma lung metastases. Curr Cancer Drug Targets. 2013 May;13(4):411-22. PMID: 23410027.

Zhang ZY, Schluesener HJ. Oral administration of histone deacetylase inhibitor MS-275 ameliorates neuroinflammation and cerebral amyloidosis and improves behavior in a mouse model. J Neuropathol Exp Neurol. 2013 Mar;72(3):178-85. PMID: 23399896.

" Xi Not dangerous goods.

LKT E5477 Entinostat 25 mg 758.4 Benzamide; HDAC1 inhibitor. N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester SNDX-275; MS-275; 209783-80-2    ≥98% 376.41 C21H20N4O3 C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3 Ambient Ambient "Shah P, Gau Y, Sabnis G. Histone deacetylase inhibitor entinostat reverses epithelial to mesenchymal transition of breast cancer cells by reversing the repression of E-cadherin. Breast Cancer Res Treat. 2013 Dec 5. [Epub ahead of print]. PMID: 24305977.

Zhu S, Denman CJ, Cobanoglu ZS, et al. The Narrow-Spectrum HDAC Inhibitor Entinostat Enhances NKG2D Expression Without NK Cell Toxicity, Leading to Enhanced Recognition of Cancer Cells. Pharm Res. 2013 Nov 8. [Epub ahead of print]. PMID: 24203492.

Kennedy PJ, Feng J, Robison AJ, et al. Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nat Neurosci. 2013 Apr;16(4):434-40. PMID: 23475113.

Rao-Bindal K, Koshkina NV, Stewart J, et al. The histone deacetylase inhibitor, MS-275 (entinostat), downregulates c-FLIP, sensitizes osteosarcoma cells to FasL, and induces the regression of osteosarcoma lung metastases. Curr Cancer Drug Targets. 2013 May;13(4):411-22. PMID: 23410027.

Zhang ZY, Schluesener HJ. Oral administration of histone deacetylase inhibitor MS-275 ameliorates neuroinflammation and cerebral amyloidosis and improves behavior in a mouse model. J Neuropathol Exp Neurol. 2013 Mar;72(3):178-85. PMID: 23399896.

" Xi Not dangerous goods.

LKT H9814 25-Hydroxyvitamin D2 1 mg 265 Vitamin D2, ergocalciferol metabolite; VDR agonist. (E,3S,6S)-6-[(1R,3aR,4E,7aS)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylidene-cyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2,3-dimethyl-hept-4-en-2-ol 21343-40-8 ≥90% 412.65 C28H44O2 CC(C=CC(C)C(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C Ambient -20°C "Shah I, Petroczi A, Tabet N, et al. Low 25OH vitamin D2 levels found in untreated Alzheimer's patients, compared to acetylcholinesterase-inhibitor treated and controls. Curr Alzheimer Res. 2012 Nov;9(9):1069-76. PMID: 22876849.

Houghton LA, Vieth R. The case against ergocalciferol (vitamin D2) as a vitamin supplement. Am J Clin Nutr. 2006 Oct;84(4):694-7. PMID: 17023693.

" "UN number: 2811     Class: 6.1     Packing Group: II

Proper shipping name: Toxic solid, organic, n.o.s. (25-Hydroxyvitamin D2)"

LKT H9814 25-Hydroxyvitamin D2 5 mg 1141.6 Vitamin D2, ergocalciferol metabolite; VDR agonist. (E,3S,6S)-6-[(1R,3aR,4E,7aS)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylidene-cyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2,3-dimethyl-hept-4-en-2-ol 21343-40-8 ≥90% 412.65 C28H44O2 CC(C=CC(C)C(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C Ambient -20°C "Shah I, Petroczi A, Tabet N, et al. Low 25OH vitamin D2 levels found in untreated Alzheimer's patients, compared to acetylcholinesterase-inhibitor treated and controls. Curr Alzheimer Res. 2012 Nov;9(9):1069-76. PMID: 22876849.

Houghton LA, Vieth R. The case against ergocalciferol (vitamin D2) as a vitamin supplement. Am J Clin Nutr. 2006 Oct;84(4):694-7. PMID: 17023693.

" "UN number: 2811     Class: 6.1     Packing Group: II

Proper shipping name: Toxic solid, organic, n.o.s. (25-Hydroxyvitamin D2)"

LKT H9815 25-Hydroxyvitamin D3 1 mg 88.3 Vitamin D, calcitriol prodrug; VDR agonist. Calcifediol, calcidiol, 25-hydroxycholecalciferol 19356-17-3 ≥98% 400.64 C27H44O2 CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C Ambient -20°C "Wang Q, Li H, Xie H, et al. 25-Hydroxyvitamin D3 attenuates experimental periodontitis through downregulation of TLR4 and JAK1/STAT3 signaling in diabetic mice. J Steroid Biochem Mol Biol. 2013 May;135:43-50. PMID: 23333931.

Li H, Xie H, Fu M, et al. 25-hydroxyvitamin D3 ameliorates periodontitis by modulating the expression of inflammation-associated factors in diabetic mice. Steroids. 2013 Feb;78(2):115-20. PMID: 23138030.

Ritter CS, Brown AJ. Direct suppression of Pth gene expression by the vitamin D prohormones doxercalciferol and calcidiol requires the vitamin D receptor. J Mol Endocrinol. 2011 Feb 15;46(2):63-6. PMID: 21169421.

Tuohimaa P, Golovko O, Kalueff A, et al. Calcidiol and prostate cancer. J Steroid Biochem Mol Biol. 2005 Feb;93(2-5):183-90. PMID: 15860261.

van Leeuwen JP, van Driel M, van den Bemd GJ, et al. Vitamin D control of osteoblast function and bone extracellular matrix mineralization. Crit Rev Eukaryot Gene Expr. 2001;11(1-3):199-226. PMID: 11693961.

" T+ "UN number: 2811     Class: 6.1     Packing group: II

Proper shipping name: Toxic solids, organic, n.o.s. (25-Hydroxyvitamin D3)

Reportable Quantity (RQ):     Marine pollutant: No      Poison inhalation hazard: No"

LKT H9815 25-Hydroxyvitamin D3 5 mg 394.2 Vitamin D, calcitriol prodrug; VDR agonist. Calcifediol, calcidiol, 25-hydroxycholecalciferol 19356-17-3 ≥98% 400.64 C27H44O2 CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C Ambient -20°C "Wang Q, Li H, Xie H, et al. 25-Hydroxyvitamin D3 attenuates experimental periodontitis through downregulation of TLR4 and JAK1/STAT3 signaling in diabetic mice. J Steroid Biochem Mol Biol. 2013 May;135:43-50. PMID: 23333931.

Li H, Xie H, Fu M, et al. 25-hydroxyvitamin D3 ameliorates periodontitis by modulating the expression of inflammation-associated factors in diabetic mice. Steroids. 2013 Feb;78(2):115-20. PMID: 23138030.

Ritter CS, Brown AJ. Direct suppression of Pth gene expression by the vitamin D prohormones doxercalciferol and calcidiol requires the vitamin D receptor. J Mol Endocrinol. 2011 Feb 15;46(2):63-6. PMID: 21169421.

Tuohimaa P, Golovko O, Kalueff A, et al. Calcidiol and prostate cancer. J Steroid Biochem Mol Biol. 2005 Feb;93(2-5):183-90. PMID: 15860261.

van Leeuwen JP, van Driel M, van den Bemd GJ, et al. Vitamin D control of osteoblast function and bone extracellular matrix mineralization. Crit Rev Eukaryot Gene Expr. 2001;11(1-3):199-226. PMID: 11693961.

" T+ "UN number: 2811     Class: 6.1     Packing group: II

Proper shipping name: Toxic solids, organic, n.o.s. (25-Hydroxyvitamin D3)

Reportable Quantity (RQ):     Marine pollutant: No      Poison inhalation hazard: No"

LKT G0245 Gallocatechin Gallate 5 mg 160.2 Polyphenol found in Camilla sinensis; HIV integrase inhibitor. 4233-96-9 ≥98% 458.37 C22H18O11 C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O Ambient 4°C -38° "Masler EP. Effects of catechin polyphenols and preparations from the plant-parasitic nematode Heterodera glycines on protease activity and behaviour in three nematode species. J Helminthol. 2013 May 2:1-8. [Epub ahead of print]. PMID: 23635519.

Timmel MA, Byl JA, Osheroff N. Epimerization of Green Tea Catechins during Brewing Does Not Affect the Ability to Poison Human Type II Topoisomerases. Chem Res Toxicol. 2013 Apr 4. [Epub ahead of print]. PMID: 23514406.

Bou?ová I, Hájek J, Dr?ata J, et al. Naturally occurring flavonoids as inhibitors of purified cytosolic glutathione S-transferase. Xenobiotica. 2012 Sep;42(9):872-9. PMID: 22458346.

Cao P, Raleigh DP. Analysis of the inhibition and remodeling of islet amyloid polypeptide amyloid fibers by flavanols. Biochemistry. 2012 Apr 3;51(13):2670-83. PMID: 22409724.

Jiang F, Chen W, Yi K, et al. The evaluation of catechins that contain a galloyl moiety as potential HIV-1 integrase inhibitors. Clin Immunol. 2010 Dec;137(3):347-56. PMID: 20832370.

Ko CH, Lau KM, Choy WY, et al. Effects of tea catechins, epigallocatechin, gallocatechin, and gallocatechin gallate, on bone metabolism. J Agric Food Chem. 2009 Aug 26;57(16):7293-7. PMID: 19653629.

" Xi Not dangerous goods.

LKT G0245 Gallocatechin Gallate 10 mg 254.8 Polyphenol found in Camilla sinensis; HIV integrase inhibitor. 4233-96-9 ≥98% 458.37 C22H18O11 C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O Ambient 4°C -38° "Masler EP. Effects of catechin polyphenols and preparations from the plant-parasitic nematode Heterodera glycines on protease activity and behaviour in three nematode species. J Helminthol. 2013 May 2:1-8. [Epub ahead of print]. PMID: 23635519.

Timmel MA, Byl JA, Osheroff N. Epimerization of Green Tea Catechins during Brewing Does Not Affect the Ability to Poison Human Type II Topoisomerases. Chem Res Toxicol. 2013 Apr 4. [Epub ahead of print]. PMID: 23514406.

Bou?ová I, Hájek J, Dr?ata J, et al. Naturally occurring flavonoids as inhibitors of purified cytosolic glutathione S-transferase. Xenobiotica. 2012 Sep;42(9):872-9. PMID: 22458346.

Cao P, Raleigh DP. Analysis of the inhibition and remodeling of islet amyloid polypeptide amyloid fibers by flavanols. Biochemistry. 2012 Apr 3;51(13):2670-83. PMID: 22409724.

Jiang F, Chen W, Yi K, et al. The evaluation of catechins that contain a galloyl moiety as potential HIV-1 integrase inhibitors. Clin Immunol. 2010 Dec;137(3):347-56. PMID: 20832370.

Ko CH, Lau KM, Choy WY, et al. Effects of tea catechins, epigallocatechin, gallocatechin, and gallocatechin gallate, on bone metabolism. J Agric Food Chem. 2009 Aug 26;57(16):7293-7. PMID: 19653629.

" Xi Not dangerous goods.

LKT I6804 Irbesartan 1 g 40.3 PPARγ agonist, AT1 inhibitor. 2-Butyl-3-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4,4]non-1-en-4-one Aprovel, Avapro 138402-11-6 ≥98% 428.53 C25H28N6O CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5 Ambient Ambient "Zhang ZZ, Shang QH, Jin HY, et al. Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice. J Transl Med. 2013 Sep 25;11(1):229. PMID: 24067190.

Iida Y, Xu B, Schultz GM, et al. Efficacy and mechanism of angiotensin II receptor blocker treatment in experimental abdominal aortic aneurysms. PLoS One. 2012;7(12):e49642. PMID: 23226500

Rong X, Li Y, Ebihara K, et al. Irbesartan treatment up-regulates hepatic expression of PPARalpha and its target genes in obese Koletsky (fa(k)/fa(k)) rats: a link to amelioration of hypertriglyceridaemia. Br J Pharmacol. 2010 Aug;160(7):1796-807. PMID: 20649581

de las Heras N, Martín-Fernández B, Miana M, et al. The protective effect of irbesartan in rats fed a high fat diet is associated with modification of leptin-adiponectin imbalance. J Hypertens Suppl. 2009 Aug;27(6):S37-41. PMID: 19633450.

Siragy H. Angiotensin II receptor blockers: review of the binding characteristics. Am J Cardiol. 1999 Nov 18;84(10A):3S-8S. PMID: 10588088.

" Xn Not dangerous goods.

LKT I6804 Irbesartan 5 g 70.2 PPARγ agonist, AT1 inhibitor. 2-Butyl-3-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4,4]non-1-en-4-one Aprovel, Avapro 138402-11-6 ≥98% 428.53 C25H28N6O CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5 Ambient Ambient "Zhang ZZ, Shang QH, Jin HY, et al. Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice. J Transl Med. 2013 Sep 25;11(1):229. PMID: 24067190.

Iida Y, Xu B, Schultz GM, et al. Efficacy and mechanism of angiotensin II receptor blocker treatment in experimental abdominal aortic aneurysms. PLoS One. 2012;7(12):e49642. PMID: 23226500

Rong X, Li Y, Ebihara K, et al. Irbesartan treatment up-regulates hepatic expression of PPARalpha and its target genes in obese Koletsky (fa(k)/fa(k)) rats: a link to amelioration of hypertriglyceridaemia. Br J Pharmacol. 2010 Aug;160(7):1796-807. PMID: 20649581

de las Heras N, Martín-Fernández B, Miana M, et al. The protective effect of irbesartan in rats fed a high fat diet is associated with modification of leptin-adiponectin imbalance. J Hypertens Suppl. 2009 Aug;27(6):S37-41. PMID: 19633450.

Siragy H. Angiotensin II receptor blockers: review of the binding characteristics. Am J Cardiol. 1999 Nov 18;84(10A):3S-8S. PMID: 10588088.

" Xn Not dangerous goods.

LKT I6804 Irbesartan 25 g 268 PPARγ agonist, AT1 inhibitor. 2-Butyl-3-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4,4]non-1-en-4-one Aprovel, Avapro 138402-11-6 ≥98% 428.53 C25H28N6O CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5 Ambient Ambient "Zhang ZZ, Shang QH, Jin HY, et al. Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice. J Transl Med. 2013 Sep 25;11(1):229. PMID: 24067190.

Iida Y, Xu B, Schultz GM, et al. Efficacy and mechanism of angiotensin II receptor blocker treatment in experimental abdominal aortic aneurysms. PLoS One. 2012;7(12):e49642. PMID: 23226500

Rong X, Li Y, Ebihara K, et al. Irbesartan treatment up-regulates hepatic expression of PPARalpha and its target genes in obese Koletsky (fa(k)/fa(k)) rats: a link to amelioration of hypertriglyceridaemia. Br J Pharmacol. 2010 Aug;160(7):1796-807. PMID: 20649581

de las Heras N, Martín-Fernández B, Miana M, et al. The protective effect of irbesartan in rats fed a high fat diet is associated with modification of leptin-adiponectin imbalance. J Hypertens Suppl. 2009 Aug;27(6):S37-41. PMID: 19633450.

Siragy H. Angiotensin II receptor blockers: review of the binding characteristics. Am J Cardiol. 1999 Nov 18;84(10A):3S-8S. PMID: 10588088.

" Xn Not dangerous goods.

LKT P0092 Paclitaxel, from Taxus yunnanensis 1 mg 37.5 Diterpene found in Taxus yunnanensis; microtubule depolymerization inhibitor. Taxol; Taxol A; Paxene 33069-62-4 ≥98% 853.91 C47H51NO14 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C Ambient -20°C Insoluble in water. Soluble in ethanol (18mg/mL) or DMSO (50mg/ml) "Kamath K, Smiyun G, Wilson L, et al. Mechanisms of inhibition of endothelial cell migration by taxanes. Cytoskeleton (Hoboken). 2013 Oct 23. [Epub ahead of print]. PMID: 24155271.

Caltová K, Cervinka M. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Acta Medica (Hradec Kralove). 2012;55(3):116-24. PMID: 23297519.

Jia L, Zhang S, Ye Y, et al. Paclitaxel inhibits ovarian tumor growth by inducing epithelial cancer cells to benign fibroblast-like cells. Cancer Lett. 2012 Dec 30;326(2):176-82. PMID: 22902993.

Mielgo A, Torres VA, Clair K, et al. Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules. Oncogene. 2009 Oct 8;28(40):3551-62. PMID: 19668227.

Botta M, Forli S, Magnani M, et al. Molecular modeling approaches to study the binding mode on tubulin of microtubule destabilizing and stabilizing agents. Top Curr Chem. 2009;286:279-328. PMID: 23563616.

Chen YQ, Zhu WH, Wu YQ, et al. Effects of culture conditions on callus growth and taxol formation of Taxus yunnanensis Cheng et L.K.Fu. Zhongguo Zhong Yao Za Zhi. 2000 May;25(5):269-72. PMID: 12512447.

Kumar N. Taxol-induced polymerization of purified tubulin. Mechanism of action. J Biol Chem. 1981 Oct 25;256(20):10435-41. PMID: 6116707.

Yu YH, Kim E, Park DE, et al. Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA. Eur J Pharm Biopharm. 2012 Feb;80(2):268-273. PMID: 22108492.

" Xi, Repr. 2 , Carc. Cat 3 Not dangerous goods.

LKT P0092 Paclitaxel, from Taxus yunnanensis 5 mg 65.6 Diterpene found in Taxus yunnanensis; microtubule depolymerization inhibitor. Taxol; Taxol A; Paxene 33069-62-4 ≥98% 853.91 C47H51NO14 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C Ambient -20°C Insoluble in water. Soluble in ethanol (18mg/mL) or DMSO (50mg/ml) "Kamath K, Smiyun G, Wilson L, et al. Mechanisms of inhibition of endothelial cell migration by taxanes. Cytoskeleton (Hoboken). 2013 Oct 23. [Epub ahead of print]. PMID: 24155271.

Caltová K, Cervinka M. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Acta Medica (Hradec Kralove). 2012;55(3):116-24. PMID: 23297519.

Jia L, Zhang S, Ye Y, et al. Paclitaxel inhibits ovarian tumor growth by inducing epithelial cancer cells to benign fibroblast-like cells. Cancer Lett. 2012 Dec 30;326(2):176-82. PMID: 22902993.

Mielgo A, Torres VA, Clair K, et al. Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules. Oncogene. 2009 Oct 8;28(40):3551-62. PMID: 19668227.

Botta M, Forli S, Magnani M, et al. Molecular modeling approaches to study the binding mode on tubulin of microtubule destabilizing and stabilizing agents. Top Curr Chem. 2009;286:279-328. PMID: 23563616.

Chen YQ, Zhu WH, Wu YQ, et al. Effects of culture conditions on callus growth and taxol formation of Taxus yunnanensis Cheng et L.K.Fu. Zhongguo Zhong Yao Za Zhi. 2000 May;25(5):269-72. PMID: 12512447.

Kumar N. Taxol-induced polymerization of purified tubulin. Mechanism of action. J Biol Chem. 1981 Oct 25;256(20):10435-41. PMID: 6116707.

Yu YH, Kim E, Park DE, et al. Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA. Eur J Pharm Biopharm. 2012 Feb;80(2):268-273. PMID: 22108492.

" Xi, Repr. 2 , Carc. Cat 3 Not dangerous goods.

LKT P0092 Paclitaxel, from Taxus yunnanensis 25 mg 149.9 Diterpene found in Taxus yunnanensis; microtubule depolymerization inhibitor. Taxol; Taxol A; Paxene 33069-62-4 ≥98% 853.91 C47H51NO14 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C Ambient -20°C Insoluble in water. Soluble in ethanol (18mg/mL) or DMSO (50mg/ml) "Kamath K, Smiyun G, Wilson L, et al. Mechanisms of inhibition of endothelial cell migration by taxanes. Cytoskeleton (Hoboken). 2013 Oct 23. [Epub ahead of print]. PMID: 24155271.

Caltová K, Cervinka M. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Acta Medica (Hradec Kralove). 2012;55(3):116-24. PMID: 23297519.

Jia L, Zhang S, Ye Y, et al. Paclitaxel inhibits ovarian tumor growth by inducing epithelial cancer cells to benign fibroblast-like cells. Cancer Lett. 2012 Dec 30;326(2):176-82. PMID: 22902993.

Mielgo A, Torres VA, Clair K, et al. Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules. Oncogene. 2009 Oct 8;28(40):3551-62. PMID: 19668227.

Botta M, Forli S, Magnani M, et al. Molecular modeling approaches to study the binding mode on tubulin of microtubule destabilizing and stabilizing agents. Top Curr Chem. 2009;286:279-328. PMID: 23563616.

Chen YQ, Zhu WH, Wu YQ, et al. Effects of culture conditions on callus growth and taxol formation of Taxus yunnanensis Cheng et L.K.Fu. Zhongguo Zhong Yao Za Zhi. 2000 May;25(5):269-72. PMID: 12512447.

Kumar N. Taxol-induced polymerization of purified tubulin. Mechanism of action. J Biol Chem. 1981 Oct 25;256(20):10435-41. PMID: 6116707.

Yu YH, Kim E, Park DE, et al. Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA. Eur J Pharm Biopharm. 2012 Feb;80(2):268-273. PMID: 22108492.

" Xi, Repr. 2 , Carc. Cat 3 Not dangerous goods.

LKT P0092 Paclitaxel, from Taxus yunnanensis 100 mg 337.6 Diterpene found in Taxus yunnanensis; microtubule depolymerization inhibitor. Taxol; Taxol A; Paxene 33069-62-4 ≥98% 853.91 C47H51NO14 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C Ambient -20°C Insoluble in water. Soluble in ethanol (18mg/mL) or DMSO (50mg/ml) "Kamath K, Smiyun G, Wilson L, et al. Mechanisms of inhibition of endothelial cell migration by taxanes. Cytoskeleton (Hoboken). 2013 Oct 23. [Epub ahead of print]. PMID: 24155271.

Caltová K, Cervinka M. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Acta Medica (Hradec Kralove). 2012;55(3):116-24. PMID: 23297519.

Jia L, Zhang S, Ye Y, et al. Paclitaxel inhibits ovarian tumor growth by inducing epithelial cancer cells to benign fibroblast-like cells. Cancer Lett. 2012 Dec 30;326(2):176-82. PMID: 22902993.

Mielgo A, Torres VA, Clair K, et al. Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules. Oncogene. 2009 Oct 8;28(40):3551-62. PMID: 19668227.

Botta M, Forli S, Magnani M, et al. Molecular modeling approaches to study the binding mode on tubulin of microtubule destabilizing and stabilizing agents. Top Curr Chem. 2009;286:279-328. PMID: 23563616.

Chen YQ, Zhu WH, Wu YQ, et al. Effects of culture conditions on callus growth and taxol formation of Taxus yunnanensis Cheng et L.K.Fu. Zhongguo Zhong Yao Za Zhi. 2000 May;25(5):269-72. PMID: 12512447.

Kumar N. Taxol-induced polymerization of purified tubulin. Mechanism of action. J Biol Chem. 1981 Oct 25;256(20):10435-41. PMID: 6116707.

Yu YH, Kim E, Park DE, et al. Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA. Eur J Pharm Biopharm. 2012 Feb;80(2):268-273. PMID: 22108492.

" Xi, Repr. 2 , Carc. Cat 3 Not dangerous goods.

LKT H9614 Hydrochlorothiazide 5 g 58.7 Thiazide diuretic; NCCT inhibitor, carbonic anhydrase I inhibitor. 6-chloro-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 58-93-5    ≥98% 297.74 C7H8ClN3O4S2 C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl Ambient Ambient "Kunisada M, Masaki T, Ono R, et al. Hydrochlorothiazide enhances UVA-induced DNA damage. Photochem Photobiol. 2013 May-Jun;89(3):649-54. PMID: 23331297.

Karadsheh F, Weir MR. Thiazide and thiazide-like diuretics: an opportunity to reduce blood pressure in patients with advanced kidney disease. Curr Hypertens Rep. 2012 Oct;14(5):416-20. PMID: 22886538.

Duarte JD, Cooper-DeHoff RM. Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther. 2010 Jun;8(6):793-802. PMID: 20528637.

Puscas I, Coltau M, Baican M, et al. Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action. Drugs Exp Clin Res. 1999;25(6):271-9. PMID: 10713865.

Shirley DG, Walter SJ, Laycock JF. The role of sodium depletion in hydrochlorothiazide-induced antidiuresis in Brattleboro rats with diabetes insipidus. Clin Sci Mol Med. 1978 Mar;54(3):209-15. PMID: 630797.

" T Not dangerous goods.

LKT H9614 Hydrochlorothiazide 25 g 108.9 Thiazide diuretic; NCCT inhibitor, carbonic anhydrase I inhibitor. 6-chloro-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 58-93-5    ≥98% 297.74 C7H8ClN3O4S2 C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl Ambient Ambient "Kunisada M, Masaki T, Ono R, et al. Hydrochlorothiazide enhances UVA-induced DNA damage. Photochem Photobiol. 2013 May-Jun;89(3):649-54. PMID: 23331297.

Karadsheh F, Weir MR. Thiazide and thiazide-like diuretics: an opportunity to reduce blood pressure in patients with advanced kidney disease. Curr Hypertens Rep. 2012 Oct;14(5):416-20. PMID: 22886538.

Duarte JD, Cooper-DeHoff RM. Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther. 2010 Jun;8(6):793-802. PMID: 20528637.

Puscas I, Coltau M, Baican M, et al. Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action. Drugs Exp Clin Res. 1999;25(6):271-9. PMID: 10713865.

Shirley DG, Walter SJ, Laycock JF. The role of sodium depletion in hydrochlorothiazide-induced antidiuresis in Brattleboro rats with diabetes insipidus. Clin Sci Mol Med. 1978 Mar;54(3):209-15. PMID: 630797.

" T Not dangerous goods.

LKT N3301 Niacin 10 g 30.2 Vitamin B, required for formation of NAD and NADP; GPR109A agonist, hepatic diacylglycerol acyltransferase-2 inhibitor. Nicotinic acid 59-67-6    ≥98% 123.11 C6H5NO2 C1=CC(=CN=C1)C(=O)O Ambient Ambient Soluble in water (16 mg/mL). "Creider JC, Hegele RA, Joy TR. Niacin: another look at an underutilized lipid-lowering medication. Nat Rev Endocrinol. 2012 Sep;8(9):517-28. PMID: 22349076.

Kamanna VS, Ganji SH, Kashyap ML. The mechanism and mitigation of niacin-induced flushing. Int J Clin Pract. 2009 Sep;63(9):1369-77. PMID: 19691622.

Kamanna VS, Ganji SH, Kashyap ML. Niacin: an old drug rejuvenated. Curr Atheroscler Rep. 2009 Jan;11(1):45-51. PMID: 19080727.

Kamanna VS, Kashyap ML. Mechanism of action of niacin. Am J Cardiol. 2008 Apr 17;101(8A):20B-26B. PMID: 18375237.

" T+, Xi, T Not dangerous goods.

LKT N3301 Niacin 50 g 36.9 Vitamin B, required for formation of NAD and NADP; GPR109A agonist, hepatic diacylglycerol acyltransferase-2 inhibitor. Nicotinic acid 59-67-6    ≥98% 123.11 C6H5NO2 C1=CC(=CN=C1)C(=O)O Ambient Ambient Soluble in water (16 mg/mL). "Creider JC, Hegele RA, Joy TR. Niacin: another look at an underutilized lipid-lowering medication. Nat Rev Endocrinol. 2012 Sep;8(9):517-28. PMID: 22349076.

Kamanna VS, Ganji SH, Kashyap ML. The mechanism and mitigation of niacin-induced flushing. Int J Clin Pract. 2009 Sep;63(9):1369-77. PMID: 19691622.

Kamanna VS, Ganji SH, Kashyap ML. Niacin: an old drug rejuvenated. Curr Atheroscler Rep. 2009 Jan;11(1):45-51. PMID: 19080727.

Kamanna VS, Kashyap ML. Mechanism of action of niacin. Am J Cardiol. 2008 Apr 17;101(8A):20B-26B. PMID: 18375237.

" T+, Xi, T Not dangerous goods.

LKT V0146 Valsartan 1 g 41.9 AT1 inhibitor. N-(1-Oxopentyl)-N-[[2’-1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-L-valine 137862-53-4 ≥98% 435.52 C24H29N5O3 CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(C(C)C)C(=O)O Ambient Ambient "Wu X, He L, Cai Y, et al. Induction of autophagy contributes to the myocardial protection of valsartan against ischemia reperfusion injury. Mol Med Rep. 2013 Dec;8(6):1824-30. PMID: 24084854.

Sohn YI, Lee NJ, Chung A, et al. Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking. Biochem Biophys Res Commun. 2013 Oct 4;439(4):464-70. PMID: 24012668.

Cheng CI, Hsiao CC, Wu SC, et al. Valsartan impairs angiogenesis of mesenchymal stem cells through Akt pathway. Int J Cardiol. 2013 Sep 10;167(6):2765-74. PMID: 22805546.

Al-Mazroua HA, Al-Rasheed NM, Korashy HM. Downregulation of the cardiotrophin-1 gene expression by valsartan and spironolactone in hypertrophied heart rats in vivo and rat cardiomyocyte H9c2 cell line in vitro: a novel mechanism of cardioprotection. J Cardiovasc Pharmacol. 2013 Apr;61(4):337-44. PMID: 23288202.

Iwashita M, Sakoda H, Kushiyama A, et al. Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes. Am J Physiol Endocrinol Metab. 2012 Feb 1;302(3):E286-96. PMID: 22045314.

Müller DN, Mervaala EM, Dechend R, et al. Angiotensin II (AT(1)) receptor blockade reduces vascular tissue factor in angiotensin II-induced cardiac vasculopathy. Am J Pathol. 2000 Jul;157(1):111-22. PMID: 10880382.

Izumi S, Nozaki Y, Maeda K, et al. Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions. Drug Metab Dispos. 2015 Feb;43(2):235-247. PMID: 25414411.

" Xi Not dangerous goods.

LKT V0146 Valsartan 5 g 75.3 AT1 inhibitor. N-(1-Oxopentyl)-N-[[2’-1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-L-valine 137862-53-4 ≥98% 435.52 C24H29N5O3 CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(C(C)C)C(=O)O Ambient Ambient "Wu X, He L, Cai Y, et al. Induction of autophagy contributes to the myocardial protection of valsartan against ischemia reperfusion injury. Mol Med Rep. 2013 Dec;8(6):1824-30. PMID: 24084854.

Sohn YI, Lee NJ, Chung A, et al. Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking. Biochem Biophys Res Commun. 2013 Oct 4;439(4):464-70. PMID: 24012668.

Cheng CI, Hsiao CC, Wu SC, et al. Valsartan impairs angiogenesis of mesenchymal stem cells through Akt pathway. Int J Cardiol. 2013 Sep 10;167(6):2765-74. PMID: 22805546.

Al-Mazroua HA, Al-Rasheed NM, Korashy HM. Downregulation of the cardiotrophin-1 gene expression by valsartan and spironolactone in hypertrophied heart rats in vivo and rat cardiomyocyte H9c2 cell line in vitro: a novel mechanism of cardioprotection. J Cardiovasc Pharmacol. 2013 Apr;61(4):337-44. PMID: 23288202.

Iwashita M, Sakoda H, Kushiyama A, et al. Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes. Am J Physiol Endocrinol Metab. 2012 Feb 1;302(3):E286-96. PMID: 22045314.

Müller DN, Mervaala EM, Dechend R, et al. Angiotensin II (AT(1)) receptor blockade reduces vascular tissue factor in angiotensin II-induced cardiac vasculopathy. Am J Pathol. 2000 Jul;157(1):111-22. PMID: 10880382.

Izumi S, Nozaki Y, Maeda K, et al. Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions. Drug Metab Dispos. 2015 Feb;43(2):235-247. PMID: 25414411.

" Xi Not dangerous goods.

LKT V0146 Valsartan 25 g 276.3 AT1 inhibitor. N-(1-Oxopentyl)-N-[[2’-1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-L-valine 137862-53-4 ≥98% 435.52 C24H29N5O3 CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(C(C)C)C(=O)O Ambient Ambient "Wu X, He L, Cai Y, et al. Induction of autophagy contributes to the myocardial protection of valsartan against ischemia reperfusion injury. Mol Med Rep. 2013 Dec;8(6):1824-30. PMID: 24084854.

Sohn YI, Lee NJ, Chung A, et al. Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking. Biochem Biophys Res Commun. 2013 Oct 4;439(4):464-70. PMID: 24012668.

Cheng CI, Hsiao CC, Wu SC, et al. Valsartan impairs angiogenesis of mesenchymal stem cells through Akt pathway. Int J Cardiol. 2013 Sep 10;167(6):2765-74. PMID: 22805546.

Al-Mazroua HA, Al-Rasheed NM, Korashy HM. Downregulation of the cardiotrophin-1 gene expression by valsartan and spironolactone in hypertrophied heart rats in vivo and rat cardiomyocyte H9c2 cell line in vitro: a novel mechanism of cardioprotection. J Cardiovasc Pharmacol. 2013 Apr;61(4):337-44. PMID: 23288202.

Iwashita M, Sakoda H, Kushiyama A, et al. Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes. Am J Physiol Endocrinol Metab. 2012 Feb 1;302(3):E286-96. PMID: 22045314.

Müller DN, Mervaala EM, Dechend R, et al. Angiotensin II (AT(1)) receptor blockade reduces vascular tissue factor in angiotensin II-induced cardiac vasculopathy. Am J Pathol. 2000 Jul;157(1):111-22. PMID: 10880382.

Izumi S, Nozaki Y, Maeda K, et al. Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions. Drug Metab Dispos. 2015 Feb;43(2):235-247. PMID: 25414411.

" Xi Not dangerous goods.

LKT C2961 Chondroitin Sulfate, chicken 5 g 51.1 Polyanionic sulfated glycosaminoglycan, endogenous component of connective tissues. Chondroitinsulfuric acid; Chonsurid; Structum 9007-28-7 ≥90% 50000 C13H21NO15S CC(=O)NC1C(C(C(OC1O)OS(=O)(=O)O)O)OC2C(C(C(C(O2)C(=O)O)O)O)O Hygroscopic. Ambient 4°C Soluble in water. "Henrotin Y, Mathy M, Sanchez C, et al. Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations. Ther Adv Musculoskelet Dis. 2010 Dec;2(6):335-48. PMID: 22870459.

Campo GM, Avenoso A, Campo S, et al. Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes. J Cell Biochem. 2009 Jan 1;106(1):83-92. PMID: 19009563.

Campo GM, Avenoso A, Campo S, et al. Chondroitin-4-sulphate inhibits NF-kB translocation and caspase activation in collagen-induced arthritis in mice. Osteoarthritis Cartilage. 2008 Dec;16(12):1474-83.  PMID: 18501644.

Chou MM, Vergnolle N, McDougall JJ, et al. Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Exp Biol Med (Maywood). 2005 Apr;230(4):255-62. PMID: 15792947.

Cho SY, Sim JS, Jeong CS, et al. Effects of low molecular weight chondroitin sulfate on type II collagen-induced arthritis in DBA/1J mice. Biol Pharm Bull. 2004 Jan;27(1):47-51. PMID: 14709897.

Campo GM, Avenoso A, Campo S, et al. Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats. Arthritis Res Ther. 2003;5(3):R122-31.  PMID: 12723984.

Omata T, Itokazu Y, Inoue N, et al. Effects of chondroitin sulfate-C on articular cartilage destruction in murine collagen-induced arthritis. Arzneimittelforschung. 2000 Feb;50(2):148-53. PMID: 10719618.

" Not dangerous goods.

LKT C2961 Chondroitin Sulfate, chicken 25 g 196.8 Polyanionic sulfated glycosaminoglycan, endogenous component of connective tissues. Chondroitinsulfuric acid; Chonsurid; Structum 9007-28-7 ≥90% 50000 C13H21NO15S CC(=O)NC1C(C(C(OC1O)OS(=O)(=O)O)O)OC2C(C(C(C(O2)C(=O)O)O)O)O Hygroscopic. Ambient 4°C Soluble in water. "Henrotin Y, Mathy M, Sanchez C, et al. Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations. Ther Adv Musculoskelet Dis. 2010 Dec;2(6):335-48. PMID: 22870459.

Campo GM, Avenoso A, Campo S, et al. Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes. J Cell Biochem. 2009 Jan 1;106(1):83-92. PMID: 19009563.

Campo GM, Avenoso A, Campo S, et al. Chondroitin-4-sulphate inhibits NF-kB translocation and caspase activation in collagen-induced arthritis in mice. Osteoarthritis Cartilage. 2008 Dec;16(12):1474-83.  PMID: 18501644.

Chou MM, Vergnolle N, McDougall JJ, et al. Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Exp Biol Med (Maywood). 2005 Apr;230(4):255-62. PMID: 15792947.

Cho SY, Sim JS, Jeong CS, et al. Effects of low molecular weight chondroitin sulfate on type II collagen-induced arthritis in DBA/1J mice. Biol Pharm Bull. 2004 Jan;27(1):47-51. PMID: 14709897.

Campo GM, Avenoso A, Campo S, et al. Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats. Arthritis Res Ther. 2003;5(3):R122-31.  PMID: 12723984.

Omata T, Itokazu Y, Inoue N, et al. Effects of chondroitin sulfate-C on articular cartilage destruction in murine collagen-induced arthritis. Arzneimittelforschung. 2000 Feb;50(2):148-53. PMID: 10719618.

" Not dangerous goods.

LKT C0016 Caerulomycin A 1 mg 388.3 Bipyridamine toxin. Cerulomycin 21802-37-9 ≥96% 229.23 C12H11N3O2 COC1=CC(=CN=O)NC(=C1)C2=CC=CC=N2 Ambient -20°C "Zhu Y, Zhang Q, Li S, et al. Insights into Caerulomycin A Biosynthesis: A Two-Component Monooxygenase CrmH-Catalyzed Oxime Formation. J Am Chem Soc. 2013 Dec 5. [Epub ahead of print]. PMID: 24295370.

Cristalli G, Franchetti P, Grifantini M, et al. 2,2'-Bipyridyl-6-carboxamidoximes with potential antitumor and antimicrobial properties. Farmaco Sci. 1986 Jul;41(7):499-507. PMID: 3743743

Chatterjee DK, Raether W, Iyer N, et al. Caerulomycin, an antifungal antibiotic with marked in vitro and in vivo activity against Entamoeba histolytica. Z Parasitenkd. 1984;70(5):569-73. PMID: 6095553.

" Not dangerous goods.

LKT P7057 Protodioscin 5 mg 120.4 Saponin found in Dioscorea; Na+/K+ ATPase and Ca2+/Mg2+ ATPase activator. 55056-80-9 ≥98% 1049.19 C50H82O22 CC1C2C(CC3C2(CCC4C3CC=C5C4(CCC(C5)OC6C(C(C(C(O6)CO)OC7C(C(C(C(O7)C)O)O)O)O)OC8C(C(C(C(O8)C)O)O)O)C)C)OC1(CCC(C)COC9C(C(C(C(O9)CO)O)O)O)O Ambient Ambient "Wang T, Choi RC, Li J, et al. Antihyperlipidemic effect of protodioscin, an active ingredient isolated from the rhizomes of Dioscorea nipponica. Planta Med. 2010 Oct;76(15):1642-6. PMID: 20509104.

Ning Z, Li YK, Zhou Y. Effect and mechanism of methyl protodioscin in protecting cardiomyocytes against anoxia/reoxygenation injury. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Apr;30(4):407-9. PMID: 20669680.

He X, Qiao A, Wang X, et al. Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines. Steroids. 2006 Sep;71(9):828-33. PMID: 16797625.

Wang G, Chen H, Huang M, et al. Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. Cancer Lett. 2006 Sep 8;241(1):102-9. PMID: 16458429.

Hu K, Yao X. The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro. Cancer Invest. 2003 Jun;21(3):389-93. PMID: 12901285.

Hu K, Yao X. Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel. Planta Med. 2002 Apr;68(4):297-301. PMID: 11988850.

" U/A Not dangerous goods.

LKT P7057 Protodioscin 25 mg 468.8 Saponin found in Dioscorea; Na+/K+ ATPase and Ca2+/Mg2+ ATPase activator. 55056-80-9 ≥98% 1049.19 C50H82O22 CC1C2C(CC3C2(CCC4C3CC=C5C4(CCC(C5)OC6C(C(C(C(O6)CO)OC7C(C(C(C(O7)C)O)O)O)O)OC8C(C(C(C(O8)C)O)O)O)C)C)OC1(CCC(C)COC9C(C(C(C(O9)CO)O)O)O)O Ambient Ambient "Wang T, Choi RC, Li J, et al. Antihyperlipidemic effect of protodioscin, an active ingredient isolated from the rhizomes of Dioscorea nipponica. Planta Med. 2010 Oct;76(15):1642-6. PMID: 20509104.

Ning Z, Li YK, Zhou Y. Effect and mechanism of methyl protodioscin in protecting cardiomyocytes against anoxia/reoxygenation injury. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Apr;30(4):407-9. PMID: 20669680.

He X, Qiao A, Wang X, et al. Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines. Steroids. 2006 Sep;71(9):828-33. PMID: 16797625.

Wang G, Chen H, Huang M, et al. Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. Cancer Lett. 2006 Sep 8;241(1):102-9. PMID: 16458429.

Hu K, Yao X. The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro. Cancer Invest. 2003 Jun;21(3):389-93. PMID: 12901285.

Hu K, Yao X. Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel. Planta Med. 2002 Apr;68(4):297-301. PMID: 11988850.

" U/A Not dangerous goods.

LKT G0243 (?)-Gallocatechin 5 mg 83.7 Polyphenol found in Camilla sinensis; HIV integrase and RT inhibitor, α-amylase inhibitor. 3371-27-5 ≥98% 306.27 C15H14O7 C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)O Ambient 4°C "Tsujita T, Shintani T, Sato H. α-Amylase inhibitory activity from nut seed skin polyphenols. 1. Purification and characterization of almond seed skin polyphenols. J Agric Food Chem. 2013 May 15;61(19):4570-6. PMID: 23614772.

Colon M, Nerin C. Role of catechins in the antioxidant capacity of an active film containing green tea, green coffee, and grapefruit extracts. J Agric Food Chem. 2012 Oct 3;60(39):9842-9. PMID: 22973940.

F Vale LH, Mendes MM, Fernandes RS, et al. Protective effect of schizolobium parahyba flavonoids against snake venoms and isolated toxins. Curr Top Med Chem. 2011;11(20):2566-77. PMID: 21682680

Jiang Y, Ng TB, Liu Z, et al. Immunoregulatory and anti-HIV-1 enzyme activities of antioxidant components from lotus (Nelumbo nucifera Gaertn) rhizome. Biosci Rep. 2010 Nov 30. PMID: 21114474.

Ko CH, Lau KM, Choy WY, et al. Effects of tea catechins, epigallocatechin, gallocatechin, and gallocatechin gallate, on bone metabolism. J Agric Food Chem. 2009 Aug 26;57(16):7293-7. PMID: 19653629.

Ferrazzano GF, Amato I, Ingenito A, et al. Anti-cariogenic effects of polyphenols from plant stimulant beverages (cocoa, coffee, tea). Fitoterapia. 2009 Jul;80(5):255-62. PMID: 19397954.

" Xi Not dangerous goods.

LKT G0243 (?)-Gallocatechin 10 mg 150.7 Polyphenol found in Camilla sinensis; HIV integrase and RT inhibitor, α-amylase inhibitor. 3371-27-5 ≥98% 306.27 C15H14O7 C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)O Ambient 4°C "Tsujita T, Shintani T, Sato H. α-Amylase inhibitory activity from nut seed